Ovarian cancer stem cells and targeted therapy
نویسندگان
چکیده
منابع مشابه
Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy.
Although initially responsive to chemotherapy, many patients with ovarian cancer subsequently develop relapsed and potentially fatal metastatic disease, which is thought to develop from cancer stem cells (CSCs) that are relatively resistant to conventional therapy. Here, we show that CSCs express a type I receptor tyrosine kinase-like orphan receptor (ROR1), which is expressed during embryogene...
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Ovarian cancer is a highly lethal disease among all gynecologic malignancies and is the fifth leading cause of cancer-related death in women. Although the standard combination of surgery and chemotherapy was initially effective in patients with ovarian cancer, disease relapse commonly occurred due to the generation of chemoresistance. It has been reported that cancer stem cells (CSCs) are invol...
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ژورنال
عنوان ژورنال: Journal of Ovarian Research
سال: 2019
ISSN: 1757-2215
DOI: 10.1186/s13048-019-0588-z